No Conventional Function for the Conventional Kinesin?
نویسندگان
چکیده
منابع مشابه
Physical analysis of a processive molecular motor: the conventional kinesin.
We present a model that allows for the derivation of the experimentally accessible observables: spatial steps, mean velocity, stall force, useful power, efficiency and randomness, etc. as a function of the [adenosine triphosphate] concentration and an external load F. The model presents a minimum of adjustable parameters and the theoretical predictions compare well with the available experiment...
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Conventional kinesin is a ubiquitous organelle transporter that moves cargo toward the plus-ends of microtubules. In addition, several in vitro studies indicated a role of conventional kinesin in cross-bridging and sliding microtubules, but in vivo evidence for such a role is missing. In this study, we show that conventional kinesin mediates microtubule-microtubule interactions in the model fun...
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Null mutations in the Drosophila Kinesin heavy chain gene (Khc), which are lethal during the second larval instar, have shown that conventional kinesin is critical for fast axonal transport in neurons, but its functions elsewhere are uncertain. To test other tissues, single imaginal cells in young larvae were rendered null for Khc by mitotic recombination. Surprisingly, the null cells produced ...
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essential to axonal tubulin transport is lost or inhibited 2 days after axotomy. This inhibition is not due to the depletion of conventional kinesin. It could be due to the inactivation of conventional kinesin or to the inactivation or depletion of some other motor or factor essential to axonal tubulin transport. This model of protein transport in the squid giant axon may facilitate the identif...
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ژورنال
عنوان ژورنال: Traffic
سال: 2008
ISSN: 1398-9219,1600-0854
DOI: 10.1111/j.1600-0854.2008.00818.x